A facile route to flavone and neoflavone backbones via a regioselective palladium catalyzed oxidative Heck reaction

Abstract

A straightforward and atom-economical base-free palladium-catalyzed regioselective direct arylation of coumarins and chromenones is devised. This protocol is compatible with a wide variety of electron-donating and -withdrawing substituents and allows construction of various biologically important flavone and neoflavone backbones.