Dilution Anemia Corrected by Splenectomy in Gaucher's Disease

Abstract

Case Studies1 April 1963Dilution Anemia Corrected by Splenectomy in Gaucher's DiseaseA. J. BOWDLER, M.B., B.SC., M.R.C.P.A. J. BOWDLER, M.B., B.SC., M.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-664 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGaucher's disease is commonly accompanied. by anemia, which is usually ascribed to the replacement of bone marrow by colonization with the cerebroside-laden Gaucher cells; occasionally it may be due to hemorrhages conditioned by thrombocytopenia, and very rarely there has been described an associated acquired hemolytic anemia (1, 2).The present case illustrates a further mechanism by which the level of circulating hemoglobin may be depressed in this disease: the total circulating red cell mass was within normal limits, but the plasma volume (and thus the total blood volume) was greatly expanded, so that anemia arose from the dilution of the...References1. THANNHAUSER SJ: Lipidoses. Diseases of the Intracellular Lipid Metabolism, 3d ed., Grune & Stratton, Inc., New York and London, 1958, p. 497. Google Scholar2. MANDELBAUMBERGERLEDERER HLM: Gaucher's disease. I. A case with hemolytic anemia and marked thrombopenia; improvement after removal of spleen weighing 6822 grams. Ann. Intern. Med. 16: 438, 1942. LinkGoogle Scholar3. CHAPLINMOLLISON HPL: Correction for plasma trapped in the red cell column of the hematocrit. Blood 7: 1227, 1952. CrossrefMedlineGoogle Scholar4. HARRISMCALLISTERPRANKERD IMJTA: Splenomegaly and the circulating red cell. Brit. J. Haemat. 4: 97, 1958. CrossrefMedlineGoogle Scholar5. MOTULSKYCASSERDGIBLETT AGEE: In vivo measurement of splenic circulation: rapid method for demonstration of splenic red cell sequestration. J. Clin. Invest. 35: 725, 1956. Google Scholar6. BOWDLER AJ: Theoretical considerations concerning measurement of the splenic red cell pool. Clin. Sci. 23: 181, 1962. MedlineGoogle Scholar7. 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BERLINLAWRENCEGARTLAND NIJHJ: The blood volume in chronic leukemia as determined by P32 labelled red blood cells. J. Lab. Clin. Med. 36: 435, 1950. MedlineGoogle Scholar14. ROTHSCHILDBAUMANYALOWBERSON MAARSSA: Effect of splenomegaly on blood volume. J. Appl. Physiol. 6: 701, 1954. CrossrefMedlineGoogle Scholar15. MCFADZEANTODDTSANG AJDKC: Observations on the anemia of cryptogenetic splenomegaly. I. Hemolysis. Blood 13: 513, 1958. CrossrefMedlineGoogle Scholar16. MCFADZEANTODDTSANG AJDKC: Observations on the anemia of cryptogenetic splenomegaly. II. Expansion of the plasma volume. Blood 13: 524, 1958. CrossrefMedlineGoogle Scholar17. PERERA GA: The plasma volume in Laennec's cirrhosis of the liver. Ann. Intern. Med. 24: 643, 1946. LinkGoogle Scholar18. EISENBERG S: Blood volume in patients with Laennec's cirrhosis of the liver as determined by radioactive chromium-tagged red cells. Amer. J. Med. 20: 189, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London,Dr. Bowdler carried out this investigation as Bilton Pollard Fellow, Medical Unit, University College Hospital Medical School, London, England.Requests for reprints should be addressed to A. J. Bowdler, M. B., Department of Medicine, University of Rochester School of Medicine and Dentistry, 260 Crittenden Boulevard, Rochester 20, New York. 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ROSSI, M.D.Blood Volume Studies in Patients with SplenomegalyStudies on the Haemodilution Anaemia of SplenomegalyBLOOD-VOLUME AND THE SPLEENEFFECT OF SPLENECTOMY ON THE HÆMODILUTIONAL ANÆMIA OF SPLENOMEGALYThe tropical splenomegaly syndromeHaematological Effects of the Idiopathic Splenomegaly Seen in UgandaDilution Anaemia Associated with Enlargement of SpleenDie gleichzeitige Bestimmung von Plasmavolumen und Gesamterythrozytenmenge mit51Cr und125I-Albumin sowie ein Beitrag zur Beziehung zwischen peripherem und Körperhämatokrit bei hämatologischen ErkrankungenTHE RADIOSPLENOGRAM IN NORMAL SUBJECTS AND IN PATIENTS WITH SPLENOMEGALYAnämie und Gesamtmenge zirkulierender Erythrocyten bei OsteomyeloskleroseUntersuchungen zu den Blutbildveränderungen bei LeberzirrhoseHÆMODILUTION ANÆMIA ASSOCIATED WITH SIMPLE SPLENIC HYPERPLASIA 1 April 1963Volume 58, Issue 4Page: 664-669KeywordsAnemiaBlood plasmaBlood volumeBone marrowCellsHemoglobinHemolytic anemiaHemorrhagePlasma volumeSplenectomy Issue Published: 1 April 1963 PDF downloadLoading ...