Malignant Granuloma of the Face: Contribution to Its Nosology

Abstract

Since McBride¹⁸reported, in 1896, the first case of malignant granuloma, only scattered observations have been published in several countries. Gottesberge,¹⁴however, presented seven cases. A review of the literature was done recently by Terracol³²(1954), who called attention to the abundant synonimia, mentioning nasal malignant granuloma, granuloma gangraenescens, sarco lupo pernio, nasal and facial mutilating mortal granuloma, mortal progressive granulomatous ulceration of the nose, gangrenous osteomyelitis of the paranasal sinus, nasal chronic infectious granuloma of unknown cause, idiopathic granuloma of the facial medial tissues, facial mycosis fungoides, pseudotumoral inflammation, malignant reticulosis, malignant mesenchymoma of the nasal-maxillary region, etc. The entity is more frequent in adult males and rare in children. The most characteristic feature of the disease is the ulcerous-necrotic process, progressing inexorably and resisting any therapeutic measures, as it has been observed in the majority of the cases studied. Its features were described by Stewart