JNCI Journal of the National Cancer Institute · 1973 · 10 citations · 0 references
Veterinary MedicineOncologyPathologyCarcinogenesisCellular MetabolismNeoplasiaEpithelial TumorsMammary Epithelial Cell BiologyMammary Gland DevelopmentMammary TumorsIsoenzyme AnalysisIsoenzyme SpecificityMammary Epithelial Cell MetabolismMammary Epithelial MetabolismMammary Gland HistologyMammary Gland MetabolismMammary GlandsNeoplastic Progression
The mammary glands of virgin, pregnant, and lactating BALB/c mice, the preneoplastic hyperplastic alveolar-nodule outgrowths, and mammary adenocarcinomas from BALB/c mice were examined for glucose-6-phosphate dehydrogenase (G6PD) isoenzymes. Normal mammary gland contained 2 isoenzymes (G6PD-2, G6PD-3), whereas a third, more rapidly migrating isoenzyme (G6PD-1) was found in significant levels only in the preneoplastic and neoplastic mammary tissues. Thus expression of a specific G6PD isoenzyme seems related to neoplastic transformation.