The Mechanism of Hypoalbuminemia in Rheumatoid Arthritis

Abstract

Article1 July 1965The Mechanism of Hypoalbuminemia in Rheumatoid ArthritisPATRICIA WILKINSON, M.D., ROSS JEREMY, M.B., FRANK P. BROOKS, M.D., F.A.C.P., JOSEPH L. HOLLANDER, M.D., F.A.C.P.PATRICIA WILKINSON, M.D., ROSS JEREMY, M.B., FRANK P. BROOKS, M.D., F.A.C.P., JOSEPH L. HOLLANDER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-1-109 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypoalbuminemia is frequently encountered in rheumatoid arthritis, but the mechanism producing this abnormality has not previously been investigated. Tracer studies using isotopically labeled human albumin can help towards solving the problem. By measuring albumin turnover with I131-labeled albumin, it can be determined whether the hypoalbuminemia results from decreased synthesis or increased catabolism or if there is an abnormal distribution of the protein. If the turnover rate is increased, then Cr51-labeled albumin can be used to find out if this is due to a protein-losing gastroenteropathy (1). These techniques have been employed to study albumin metabolism in a selected group of...References1. Editorial. Protein-losing gastroenteropathy. Lancet 1: 351, 1959. MedlineGoogle Scholar2. GROSSMANYALOWWESTON JRARE: Albumin degradation and synthesis as influenced by hydrocortisone, corticotropin and infection. Metabolism 9: 528, 1960. MedlineGoogle Scholar3. ROTHSCHILDSCHREIBERORATZMC GEE MASSMHL: The effects of adrenocortical hormones on albumin metabolism studied with albumin I131. J. Clin. Invest. 37: 1229, 1958. CrossrefMedlineGoogle Scholar4. ROPESBENNETTCOBBJACOXJESSAR MWGASRRA: 1958 revision of diagnostic criteria for rheumatoid arthritis. Bull. Rheum. Dis. 9: 175, 1958. MedlineGoogle Scholar5. WALDMANN TA: Gastrointestinal protein loss demonstrated by 51Cr-labelled albumin. Lancet 2: 121, 1961. CrossrefMedlineGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Gastroenterology and Rheumatology Sections, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pa.This work was supported in part by Clinical Research Center Grant 3 MO 1 FR-40, Division of Research Facilities and Resources, National Institutes of Health, Bethesda, Md.Patricia Wilkinson, M.D., was the recipient of a Wellcome Travel Grant; Frank P. Brooks, M.D., was the recipient of Career Development Award AM-K3-2983, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Joseph L. Hollander, M.D., 206 Maloney Building, University Hospital, 3400 Spruce Street, Philadelphia, Pa. 19104. 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New oral gold compound for treatment of rheumatoid arthritis.The influence of drugs and disease activity on biochemical and haematological data in rheumatoid arthritisAlbumin metabolism in rheumatoid arthritis.The Capacity of Aspirin to Acetylate Proteins in Vitro and in VivoPresidential messageMetabolism of 131 I-labelled Albumin in Patients with Acute Infectious Liver DiseasesCHAPTER vi: THE METABOLISM OF IODINE-LABELLED TRANSFERRIN AND ALBUMIN 1 July 1965Volume 63, Issue 1Page: 109-114KeywordsAlbuminsArthritisHospital medicineProtein synthesisProteinsProteinuriaResearch facilitiesResearch grantsRheumatoid arthritisRheumatology Issue Published: 1 July 1965 PDF DownloadLoading ...