Science · 1972 · 95 citations · 6 references
Membrane StructurePotassium ConductanceSynaptic TransmissionMembrane CharacterizationNeurotransmissionChloride ConductanceSocial SciencesStructure-activity StudyMembrane TransportOsmoregulationBiophysicsBiochemistryIon ChannelsSalicylate Atnd BenzoateNervous SystemMembrane PermeationMembrane FormationNeurophysiologyPhysiologyElectrophysiologyMedicine
Salicylate atnd benzoate, and their anlalogs, reversibly increase the membrane potetntial and conductance of identified molluscan neurons by increasing potassium conductance and decreasing chloride conductance. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficients and their pK(a) values.
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