A Convenient and Practical Synthesis of Anisoles and Deuterated Anisoles by Palladium‐Catalyzed Coupling Reactions of Aryl Bromides and Chlorides

Abstract

Synthesis of anisole: Aryl and heteroaryl halides undergo selective CO cross-coupling reactions with methanol in the presence of a Pd(OAc)2/L3 catalyst system. The corresponding ethers were obtained under mild conditions in good yields. The catalytic methodology was also used for the synthesis of labeled deuterated anisoles in good yields (see scheme). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.