Endocrinology · 1977 · 68 citations · 0 references
Life SciencesEndocrinologyNeuroendocrinologyReproductive EndocrinologyReproductive PhysiologyHormone ReleaseHormone SecretionHypothalamic-pituitary RegulationMammalian EndocrinologyPituitary Hormone RegulationPituitary HormonesHypothalamic Regulation Of ProlactinHypothalamic-pituitary-prolactin AxisProlactin Release MechanismsProlactin Secretion RegulationReleasing HormonesSuppressionThyrotropin SecretionThyrotropin-releasing Hormone Regulation
Administration of antiserum to synthetic thyrotropin-releasing hormone (TRH) to male and female rats cause a 50% and a 70% suppression in serum levels of prolactin and thyrotropin, respectively, as compared with controls injected with normal rabbit serum. The degree of suppression was similar in diestrous and proestrous female rats and in male rats. These findings support the view that, in addition to its original designation, TRH also has a physiological role in regulating release of pituitary prolactin.