Accelerated DNA Adduct Formation in the Lung of the Nrf2 Knockout Mouse Exposed to Diesel Exhaust

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Ken Itoh, Tomoki Chiba, Satoru Takahashi et al. · Biochemical and Biophysical Research Communications · 1997 · 4K citations

Life Sciences, Biochemistry, Molecular Biology +14

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

Paolo Moi, Isadora Asunis, Antonio Cao et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations

Life Sciences, Genetics, Molecular Biology +17

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

Thomas H. Rushmore, Marcia R. Morton, C.B. Pickett · Journal of Biological Chemistry · 1991 · 1.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Tetsuro Ishii, Ken Itoh, Satoru Takahashi et al. · Journal of Biological Chemistry · 2000 · 1.5K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Nuclease P1-mediated enhancement of sensitivity of ³²P-Postlabeling test for structurally diverse DNA adducts

M. Vijayaraj Reddy, Kurt Randerath · Carcinogenesis · 1986 · 1K citations

Pharmacy, Molecular Biology, Toxicology +16