Inorganic Chemistry · 2010 · 37 citations · 45 references
Natural SciencesBiochemistryChemistryAnalytical ChemistryCatalysisInorganic ChemistryAcid-base ChemistryCoordination ChemistryGlycan AnalysisGlycan DegradationGlycosidic Bond HydrolysisCopper ChemistryGlycosidase ActivityGlycosidase InhibitionGlycosidase InhibitorsGlycoside Hydrolysis MechanismsReaction Kinetics Of Glycoside HydrolysisX-ray Diffraction Analysis
Three binuclear copper(II) complexes were characterized as solids by X-ray diffraction and in solution by UV/vis spectrophotometric titration, and subsequently evaluated for their glycosidase-like activity. The structure analysis revealed comparable intermetallic Cu...Cu distances (approximately 3.5 A) for the complexes 2 and 3. Despite this similarity, the composition of the complexes differs significantly in aqueous solution as revealed by spectrophotometric titrations. The hydrolysis of selected nitrophenylglycopyranosides is up to 11,000-fold accelerated over background in the presence of the copper(II) complexes in 3-(cyclohexylamino)-1-propanesulfonic acid (CAPS) buffer at pH 10.5 and 30 degrees C.
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NIST Critically Selected Stability Constants of Metal Complexes Database
RM Smith, A. E. Martell, RJ Motekaitis et al. · 2004 · 1.2K citations
Modern methods in carbohydrate synthesis
Biochimie · 1997 · 400 citations