Clinical Nuclear Medicine · 2011 · 29 citations · 10 references
MedicineOncologySurgeryGynecologic OncologyMetastasisTumor PathologyMalignant NeoplasmsMalignant TumorsPelvic Oncology ImagingPelvic Tumor SurgeryTherapy Response AssessmentTumor CharacterizationMetastatic Disease MonitoringNegative Surgical MarginsPelvic RecurrencePelvic Tumor ImagingPelvic Tumor Local RecurrencePositive Surgical MarginsSurgical Resection MarginsVascular Invasion Assessment
This is a case of a 52-year-old woman who underwent a hysterectomy to treat a large uterine perivascular epithelioid cell tumor. She was followed with serial F-18 FDG PET/CT scans due to positive surgical margins and vascular invasion on pathology. Initial surveillance PET/CT performed 6 months post surgery was negative; however, a second surveillance PET/CT performed 12 months post surgery showed an intensely FDG-avid recurrence in the pelvic surgical site. The patient received local radiotherapy, 2 cycles of taxol and carboplatin, and was placed on imatinib mesylate (Gleevec). A final PET/CT performed 6 months after initiation of therapy showed rapidly disseminating metastatic disease and the patient died 1 month later. This rare report highlights a potentially new utility of F-18 FDG PET/CT for surveillance of recurrence of a malignant uterine perivascular epithelioid cell tumor, as well as for evaluation of response to therapy.
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Clear Cell “Sugar” Tumor of the Pancreas
Giuseppe Zamboni, Maurizio Pea, Guido Martignoni et al. · The American Journal of Surgical Pathology · 1996 · 380 citations