Circular dichroism studies of isoleucine oligopeptides in solution

Abstract

Abstract A conformational analysis was carried out on a series of L ‐isoleucine oligomers having the general formula BOC‐(Ileu) n ‐OMe (n = 2–8). These oligopeptides were examined in trifluoroethanol, trifluoroethanol‐acid and mixed organic‐water media. The results indicate that these oligomers form β‐conformations beginning at the heptamer. The stability of the β‐conformations was found to be greater than those formed by oligopeptides derived from L ‐alanine.