Publication | Closed Access
Bone Mineral Density in Children and Adolescents with Juvenile Diabetes: Selective Measurement of Bone Mineral Density of Trabecular and Cortical Bone Using Peripheral Quantitative Computed Tomography
92
Citations
0
References
1995
Year
Trabecular Bone DensityOsteoporosisObesityMetabolic SyndromeBody CompositionCortical Bone DensityOsteoarthritisJuvenile DiabetesBiostatisticsRadiologyHealth SciencesBone HealthBone DensityBone MetabolismOsteocalcinBone ImagingSelective MeasurementDiabetesPhysiologyPediatricsBone Mineral DensityMedicine
Bone mineral density (BMD) was studied in 21 children and adolescents with type I diabetes and in age- and sex-matched healthy controls. BMD was selectively measured in trabecular and total bone using peripheral quantitative computed tomography (pQCT). Cortical bone density was calculated. There was a decrease of trabecular bone density (-18.9%, p < 0.01), total bone density (-9.0%, NS) and cortical bone density (-5.1%, NS) in diabetes. Trabecular bone density was inversely correlated with the duration of diabetes and the concentration of glycosylated hemoglobin (HbA1) (r = -0.48, p = 0.027 and r = -0.63, p = 0.002, respectively). Total BMD correlated inversely with HbA1 (r = -0.52, p = 0.017). pQCT allows the selective measurement of metabolically active trabecular bone where changes of mineralization first occur. We conclude that pQCT is a useful method for investigating BMD in diabetes.