Organic Letters · 2012 · 147 citations · 51 references
Natural SciencesChemistryCatalysisOrganic ChemistryOrganometallic ChemistryCatalyst DesignCatalyst PreparationCatalytic MaterialsCatalytic MechanismsDiversity-oriented SynthesisHeterocyclic ChemistryC - H Bond FunctionalizationCatalytic Reaction MechanismsHeterocycle FunctionalizationOxidative CatalysisRuthenium-catalyzed CouplingTransition Metal-catalyzed SynthesisTransition-metal-catalyzed Functionalization
Cationic ruthenium(II) complexes enabled catalytic twofold C-H bond functionalizations with weakly coordinating aromatic esters in a highly chemo-, site- and diastereo-selective as well as site selective fashion. The oxidative Fujiwara-Moritani-type alkenylation provided step-economical access to diversely substituted styrenes and proved viable in an aerobic manner. Mechanistic studies were indicative of a reversible acetate-assisted cycloruthenation step.
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