Development of a new method for detecting a mutation in the gene encoding hepatitis B virus reverse transcriptase active site (YMDD motif)

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

Lori A. Kohlstaedt, J Wang, Jonathan M. Friedman et al. · Science · 1992 · 1.9K citations

Life Sciences, Biochemistry, Molecular Biology +17

Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.

Shin-Lian Doong, Chi‐Wei Tsai, Raymond F. Schinazi et al. · Proceedings of the National Academy of Sciences · 1991 · 516 citations

Life Sciences, Infectious Diseases, Molecular Biology +16

Selection of Mutations in the Hepatitis B Virus Polymerase During Therapy of Transplant Recipients With Lamivudine

Roger Ling, David Mutimer, Mélika Ben Ahmed et al. · Hepatology · 1996 · 465 citations · Full text

Life Sciences, Infectious Diseases, Molecular Genetics +14

Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation

Maria Bartholomew, Robert W. Jansen, Lennox J. Jeffers et al. · The Lancet · 1997 · 446 citations · Full text

Pharmacy, Infectious Diseases, Pharmacotherapy +16

Mutation in Hbv Rna–Dependent Dna Polymerase Confers Resistance to Lamivudine In Vivo

Graham Tipples, Karl P. Fischer, Vincent G. Bain et al. · Hepatology · 1996 · 442 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17