Molecular epidemiological analysis of mitochondrial DNA12SrRNA A1555G,<i>GJB2,</i>and<i>SLC26A4</i>mutations in sporadic outpatients with nonsyndromic sensorineural hearing loss in China

Abstract

The mutation frequencies of MtDNA A1555G, GJB2, and SLC26A4 were 1.63%, 13.63%, and 0%, respectively, in our study cohort. The mutational hot spot of GJB2 was c.235delC, whose allele frequency was 12.68% in sporadic outpatients. Mutation frequency of GJB2 in the prelingual group was significantly higher than in the postlingual group (p < 0.05).