Chemoselective C−H Bond Activation: Ligand and Solvent Free Iron-Catalyzed Oxidative C−C Cross-Coupling of Tertiary Amines with Terminal Alkynes. Reaction Scope and Mechanism

Abstract

FeCl(2) catalyzes the oxidative C-C cross-coupling of tertiary amines with terminal alkynes into propargylamines using (t-BuO)(2) as oxidant. The reaction can be applied to aromatic and aliphatic amines and alkynes without solvent. High chemoselectivity for aminomethyl groups is due to a steric factor.