Escape and lipodystrophy in acromegaly during pegvisomant therapy, a retrospective multicentre <scp>S</scp> panish study

Abstract

A significant proportion of patients treated with pegvisomant escaped (34%); however, the majority (87%) was easily controlled with either dose increase, further medical treatment or both. Lipodystrophy developed in 15%, mostly females, and influenced the response to treatment.