Experimental and Clinical Endocrinology & Diabetes · 2009 · 55 citations · 0 references
Life SciencesBiochemistryCell BiologyAgingCell AdhesionGlycobiologyAdhesion MoleculesCell Adhesion ReceptorsEndothelial ActivationEndothelial DysfunctionInflammatory MediatorsLeukocyte AdhesionAdvanced Glycation End ProductsCellular Adhesion MoleculesDiabetes-associated Vascular ChangesEndothelial Adhesion MoleculesEndothelial Cell AdhesionEndothelial-leukocyte InteractionsIntercellular Adhesion Molecule 1Vascular Cell Adhesion Molecule 1
Advanced glycation endproducts (AGEs) possibly play a dominant role in the pathogenesis of macrovascular disease in diabetes. Recent studies could demonstrate that glycated albumin (AGE-BSA) was able to stimulate vascular cell adhesion molecule-1 (VCAM.1) on endothelial cells. The aim of this study was to find out if AGE-BSA was not only able to enhance the expression of vascular cell adhesion molecule-1, but also of intercellular adhesion molecule-1 (ICAM-1) and E-Selectin on human endothelial cells. Stimulation of endothelial cells with AGE-BSA for six hours predominantly increased the expression of VCAM-1, but ICAM-1 and E-Selectin were also upregulated as shown by immunoilluminometric assay (ILMA).