Online Analysis of Flowing Streams Using Microflow HPLC

Abstract

The application of a recently developed online HPLC reaction sampling instrument for monitoring flow chemistry reactions is described. The system was found to work well for online analysis of flowing streams at or near atmospheric pressure, allowing for convenient time-based withdrawal, dilution, and HPLC analysis of the output of flow reactors. A general study of the capability of the instrument to sample from flowing streams is presented, along with a detailed study in which the instrument is used to characterize a thermal isomerization reaction carried out using a hot-zone flow reactor.