MedicineEndocrinologyOncologyBreast OncologyCarcinogenesisEndocrine OncologyHormonal Cancer TherapyHormonal TherapyHormone-related CarcinogenesisMalignant NeoplasmsMammary TumorsTumor PromotionAntineoplastic HormonesBreast Cancer Hormonal TherapyDaily DosingEstrogen-dependent CarcinogenesisHormonal Carcinogenesis
It has been proven without doubt that mammary cancer and other types of cancer can be induced in rats by administration of estrogens. In a series of experiments with 85 rats subjected to various types of estrogenic treatment it was found that a daily dosage of 200 gamma of estrone administered intramuscularly was most suitable for the detailed study of the mechanism of cancer production in the mammary gland after 150-200 days. Injections of smaller doses would produce cancer in 350-400 days; cancer can be obtained more quickly by the implanting crystalline hormone in the form of pellets or with injections of hormone in oil. Attempts have been made to induce mammary carcinoma with estradiol and diethylstilbestrol; results from such experiments are not yet completed.
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