Concepedia

Ligations from Tyrosine Isopeptides via 12- to 19-Membered Cyclic Transition States

Vadim Popov, Siva S. Panda, Alan R. Katritzky

The Journal of Organic Chemistry · 2013 · 13 citations · 24 references

DOI

Concepts

Abstract

Efficient syntheses of O-acyl Tyr-peptides allow chemical long-range ligation (O-acyl to N-acyl transfer) via each of 12- to 19-membered cyclic transition states. The results represent the first examples of successful isopeptide ligations starting from O-acyl Tyr-peptides.

References

24

Synthesis of Proteins by Native Chemical Ligation

Philip E. Dawson, Tom W. Muir, Ian Clark‐Lewis et al. · Science · 1994 · 4.1K citations

, , +17

A “Traceless” Staudinger Ligation for the Chemoselective Synthesis of Amide Bonds

Eliana Saxon, Joshua I. Armstrong, Carolyn R. Bertozzi · Organic Letters · 2000 · 658 citations

, , +10

Synthesis of Peptides and Proteins without Cysteine Residues by Native Chemical Ligation Combined with Desulfurization

Liang Yan, Philip E. Dawson · Journal of the American Chemical Society · 2001 · 654 citations

, , +11

Staudinger Ligation:  A Peptide from a Thioester and Azide

Bradley L. Nilsson, Laura L. Kiessling, Ronald T. Raines · Organic Letters · 2000 · 515 citations

, , +8

Native Chemical Ligation at Valine

Christian Haase, Heike Rohde, Oliver Seitz · Angewandte Chemie International Edition · 2008 · 343 citations

, , +5