Codeine and Its Alternates for Pain and Cough Relief

Abstract

Editorials1 December 1969Codeine and Its Alternates for Pain and Cough ReliefNATHAN B. EDDY, M.D.NATHAN B. EDDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-6-1209 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCodeine was first isolated in 1832, 25 years after the isolation of morphine, but its chemical relationship as the methyl ether of morphine was not established until 50 years later. Its clinical use as a morphine-like substance began almost immediately, as an antitussive as early as 1838. Its clinical use spread rapidly with recognition of its relative safety and its ability to substitute for morphine in many instances. Its relative safety was evident not only because of its lesser respiratory depressant effect (even to the present relatively few cases of poisoning and extremely few fatalities have been reported), but also...References1. EDDYFRIEBELHAHNHALBACH NBHKH: A review, in The Bulletin of the World Health Organization 38: 673, 1968; 40: 1, 1969; 40: 425, 1969; 40: 720, 1969; 40: 639, 1969. MedlineGoogle Scholar2. KRUEGEREDDYSUMWALT HNBM: The pharmacology of the opium alkaloids, Public Health Rep. (suppl. 165), 1943. Google Scholar3. GRAVENSTEINDEVLOOBEECHER GSRAHK: Effect of antitussive agents on experimental and pathological cough in man. J. Appl. Physiol. 7: 119, 1954. CrossrefMedlineGoogle Scholar4. Editorial. Brit. Med. J. 1: 1165, 1964. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 7055 Wilson Lane Bethesda, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTreatment of Chronic Refractory Cough in Adults: Focus on Neuromodulators and Other Therapeutic ModalitiesCarisoprodol pharmacokinetics and distribution in the nucleus accumbens correlates with behavioral effects in rats independent from its metabolism to meprobamateCodeine versus placebo for chronic cough in childrenDoes the type of anesthetic agent affect remifentanil effect-site concentration for preventing endotracheal tube-induced cough during anesthetic emergence? Comparison of propofol, sevoflurane, and desfluraneSystems approaches and polypharmacology for drug discovery from herbal medicines: An example using licoriceCarisoprodol tolerance and precipitated withdrawalModulation of sensory nerve function and the cough reflex: Understanding disease pathogenesisSafe Use of Codeine in the Recovering Alcoholic or Addict 1 December 1969Volume 71, Issue 6Page: 1209-1212KeywordsCodeineMorphineSafety Issue Published: 1 December 1969 PDF downloadLoading ...