FEBS Letters · 1989 · 86 citations · 10 references
MedicineCancer BiologyOncologyCell SignalingMolecular Cell BiologySignal TransductionChemotherapy ResistanceCytotoxic ChemotherapyDrug ResistanceMolecular Basis Of ResistanceTherapeutic ResistanceAnticancer Drug ResistanceCell Therapy Resistance MechanismsCorrelationMitogen-activated Protein Kinase KinasePartial ReversalProtein Kinase InhibitorsReversal Of Drug ResistanceTherapeutic Resistance Mechanisms
In this report, we demonstrate a direct correlation between protein kinase C (PKC) activity and adriamycin (ADR) resistance in mouse fibrosarcoma cells. PKC activity was measured in four murine UV-2237M fibrosarcoma cell lines that differed in the degrees to which they expressed resistance to ADR, which is an inhibitor of PKC. A comparison of the four cell lines revealed a positive correlation between the level of PKC activity and resistance to ADR. Incubation of the cells with the PKC inhibitor H-7 produced a partial reversal of ADR resistance. Taken together, these results suggest a role for PKC in the mechanism of ADR resistance.
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