Neuroreport · 1999 · 43 citations · 3 references
Life SciencesNeurobiologyNeuroscienceCellular NeuroscienceMolecular NeurobiologyMolecular NeuroscienceAxonal TransportNervous TissueNeurotransmissionProtein Trafficking In NeuronsRetrograde TransportAnterograde Axonal TransportAxonal Transport PathwaysFast Axonal TransportNeuronal Axonal TransportPrion TraffickingRetrograde Axonal TransportRetrograde Transport In NeuronsSlow Axonal Transport
We studied the axonal transport of PrP(C) in hamster retinal and sciatic nerve axons. Our results show that a novel 38kDa form is the predominant form in rapid anterograde axonal transport while the 36kDa and 33kDa PrP(C) forms, abundant in nerve and brain, appear to be either stationary or slowly transported. We did not detect any significant retrograde transport of PrP(C). These results show that 38kDa PrP(C) is the form exported from the cell body to the axonal compartment where it may represent the precursor to the more abundant PrP(C) forms after its modification in nerve fibres or terminals.
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