Chemical Communications · 2001 · 60 citations · 8 references
PharmacyChemistryMedicinal ChemistryCatalysisDrug DiscoverySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryOpioid AnalgesicsOpioid PharmacologyRetrosynthetic AnalysisAldol AdditionAsymmetric Heterocycle SynthesisChiral Product SynthesisEnantioselective SynthesisRoute DiscoveryStereoselective Aldol ReactionsSynthetic Opioids
A concise enantio- and diastereocontrolled route to (−)-morphine has been developed starting from a bicyclo[3.2.1]octenone chiral building block through an acid-catalyzed tandem retro-aldol-oxonium ion-mediated hydrophenanthrene formation reaction as the key step.
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A facile procedure for acetalization under aprotic conditions
Tatsuo Tsunoda, Masako Suzuki, Ryōji Noyori · Tetrahedron Letters · 1980 · 428 citations
Engineering, Chemistry, Surgery +2
Kathlyn A. Parker, Demosthenes Fokas · Journal of the American Chemical Society · 1992 · 119 citations