Publication | Closed Access
A concise route to (−)-morphine
60
Citations
8
References
2001
Year
Key StepOpioid EpidemicBioorganic ChemistryOrganic ChemistryPharmacotherapyAnalgesiaChemistryMolecular PharmacologyMedicinal ChemistryChiral Building BlockAddiction MedicinePain ManagementStereoselective SynthesisDiversity-oriented SynthesisOpioid Use DisorderNeuropharmacologyPharmacologyConcise Enantio-Asymmetric CatalysisEnantioselective SynthesisConcise RouteNatural SciencesOpioid OverdoseMedicineSynthetic ChemistryDrug DiscoveryAnesthesiology
A concise enantio- and diastereocontrolled route to (−)-morphine has been developed starting from a bicyclo[3.2.1]octenone chiral building block through an acid-catalyzed tandem retro-aldol-oxonium ion-mediated hydrophenanthrene formation reaction as the key step.
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