Biological and Pharmaceutical Bulletin · 2000 · 129 citations · 0 references
MedicineMedicinal ChemistryPharmacologyAntimicrobial PharmacologyMolecular VirologyVirologyAntibacterial PharmacologyAntiviral PharmacologyGastrointestinal InfectionsGastrointestinal PharmacologyAntiviral Natural ProductsAntiviral Structure-activity RelationshipsFlavonoid-mediated InhibitionPediatric Antiviral PharmacologyRotavirus Gastroenteritis
The inhibitory effects of some flavonoids on the infectivity of rotavirus, which predominantly causes sporadic diarrhea in infants and young children, were investigated. Among tested flavonoids, diosmin and hesperidin had the most potent inhibitory activity on rotavirus infection. The fifty percent inhibitory concentration of both compounds was 10 microM. However, their aglycones did not have the inhibitory activity. The rutinose moiety of flavonoids should protect against the invasion of rotavirus into cells.