Raman scattering and SEM study of bio‐conjugated core‐shell CdSe/ZnS quantum dots

Abstract

Abstract Core‐shell CdSe/ZnS quantum dots are promising as bio‐luminescent markers: being conjugated to bio molecules (proteins), they serve as luminescence tags in antigen‐antibody biochemical reaction. This presents a possibility to detect, for example, the variation of the protein biomarkers to promote the early cancer diagnosis. We studied the effect of bio molecules conjugated to QDs using Raman scattering spectra, and found that in some cases the conjugation leads to noticeable variation of these spectra, so that the detection of bio molecules could be done more accurately. An explanation of the effect is proposed. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)