<i>Global status report on road safety</i>

TLDR

The study aims to evaluate the safety and efficacy of prednisone in symptomatic heart failure patients with hyperuricemia. A short‑term prednisone regimen was administered to 191 symptomatic HF patients with hyperuricemia. Prednisone significantly lowered serum uric acid and creatinine, increased urine output, improved renal function and clinical status, and was safe in these patients.

Abstract

<h3>Objective.</h3> To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia. <h3>Methods.</h3> Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid &gt; 7 mg/dl). <h3>Results.</h3> Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p &lt; 0.01) and serum creatinine by 0.17 mg/dl (p &lt; 0.01). These favorable effects were associated with a remarkable increase in urine output, improvement in renal function, and improvement in clinical status. <h3>Conclusion.</h3> Prednisone can be used safely in symptomatic HF patients with hyperuricemia.