Complementary addressed reagents carrying EDTA‐Fe(II) groups for directed cleavage of single‐stranded nucleic acids

Abstract

An octathymidylate derivative carrying an EDTA residue at its 5'‐terminus was synthesized. In the presence of Fe 2+ , O 2 and dithiotreitol, this derivative cleaves poly(dA) and poly(A) more efficiently than the non‐complementary polynucleotide poly(dT).