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Effect of High Concentrations of Free Fatty Acids on the Ventricular Fibrillation Threshold of Normal Dogs and Dogs with Acute Myocardial Infarction
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1973
Year
Animal PhysiologyThrombosisVeterinary PhysiologyVentricular FibrillationCardiovascular DiseaseAtherosclerosisNormal DogsPhysiologyFree Fatty AcidsVentricular Fibrillation ThresholdAcute Myocardial InfarctionPublic HealthMedicineCardiologyCoronary Artery DiseaseAnesthesiologyMyocardial Infarction
Marked elevation of serum free fatty acids (FFA) was induced by infusing triglyceride and heparin in 8 normal dogs, in 6 dogs immediately after coronary ligation, and in 8 dogs 3 days after ligation. The ventricular fibrillation threshold (VFT) was measured in closed chest dogs by delivering a programmed series of impulses directly to the heart via previously implanted epicardial electrodes. There was no change in the VFT after FFA elevation in the normal dogs. Dogs with coronary occlusion had lower control VFT. However, there was no further drop after FFA elevation. These data argue against a major direct role of FFA in genesis of ventricular fibrillation related to myocardial ischemia.