AIDS Research and Human Retroviruses · 1997 · 14 citations · 37 references
Life SciencesImmunologyMolecular BiologyAdaptive ImmunityImmunology Of Infectious DiseasesMolecular VirologyAntigen RecognitionAntiviral ImmunityB-cell ResponsesCell-mediated ImmunityHumoral ImmunityViral HepatitisAdaptive Antiviral ImmunityAdaptive Immune Responses To Viral InfectionB-cell EpitopesCellular Immune Response To VirusesHiv Envelope Glycoprotein AntigensRecombinant Fusion ProteinsStructural Basis Of AntigenicityT-cell Epitopes
We have developed a comparative study of antigenic and immunogenic properties of selected immunodominant HIV-1 epitopes from p24 and gp120 proteins added to C-terminally truncated hepatitis B virus (HBV) core protein and exposed on the surface of chimeric core particles. Inserted p24 (121-210) and gp120/MN (306-328) epitopes induced the appropriate humoral and cellular immune responses against HIV-1. Superficially exposed region 160-192 of p24 also showed maximal B cell immunogenicity whereas buried region 148-162 induced maximal T cell response. Both recombinant proteins were also able to be recognized in vitro by T lymphocytes of HIV-1 asymptomatic carriers.
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Mario Clerici, Janis V. Giorgi, Chen‐Cheng Chou et al. · The Journal of Infectious Diseases · 1992 · 392 citations
HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant
S L Rowland-Jones, Douglas F. Nixon, F Gotch et al. · The Lancet · 1993 · 368 citations