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Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases

Medicinal ChemistryImmediate DeactivationPharmaceutical ScienceBlood CarboxylesterasesMedicineBioanalysisPathologyAnalytical ChemistryClinical ChemistryPharmacologyActive Metabolite ChimmitecanDrug DiscoveryDrug Analysis