Concepedia

A general phosphoric acid-catalyzed desymmetrization of meso-aziridines with silylated selenium nucleophiles

Matilde Senatore, Alessandra Lattanzi, Stefano Santoro, Claudio Santi, Giorgio Della Sala

Organic & Biomolecular Chemistry · 2011 · 47 citations · 37 references

DOI

Abstract

The first example of meso-aziridine desymmetrization with selenium nucleophiles is reported. The reaction, promoted by VAPOL-hydrogen phosphate using (phenylseleno)trimethylsilane as the nucleophile, proves to be very general and highly enantioselective (84-99% ee).

References

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