Long‐term nitric oxide deficiency causes muscarinic supersensitivity and reduces β ₃ ‐adrenoceptor‐mediated relaxation, causing rat detrusor overactivity

Abstract

Long-term NO deficiency increased rat DSM contractile responses to a muscarinic agonist, accompanied by significantly enhanced K(D) values for muscarinic receptors and [(3)H]inositol phosphate accumulation in bladder. This supersensitivity for muscarinic agonists along with reductions of beta(3)-adrenoceptor-mediated relaxations indicated that overactive DSM resulted from chronic NO deficiency.