Iron-Catalyzed Grignard Cross-Coupling with Alkyl Halides Possessing β-Hydrogens

Takashi Nagano, Tamio Hayashi

Organic Letters · 2004 · 294 citations · 35 references

Concepts

Abstract

Tris(acetylacetonato)iron(III) (Fe(acac)(3)) was found to be an efficient catalyst for the cross-coupling reaction between aryl Grignard reagents and alkyl halides possessing beta-hydrogens. The reaction is applicable to secondary alkyl halides as well as primary ones. [reaction: see text]

References

35