Journal of Dermatological Treatment · 2006 · 31 citations · 13 references
MedicineDermatologyOncologyChemotherapyCutaneous OncologyDermatopathologyCutaneous NeoplasmsDrug-induced Skin ReactionsChemotherapy-induced Dermatologic ToxicityCutaneous Drug EruptionsDermal UlcerationDermatomyositis Skin DiseaseDrug-induced Skin EruptionsHydroxyurea TherapySquamous Cell Carcinoma Histology
We report the case of a 73-year-old man who had been on hydroxyurea for essential thrombocythemia since 1988. After 12 years of treatment he developed a symmetrical dermatomyositis-like eruption together with a leg ulceration and five squamous cell carcinomas of the face. The possible pathogenetic mechanisms of these known side effects are discussed.
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Mechanism of action of hydroxyurea.
John W. Yarbro · PubMed · 1992 · 408 citations
Hydroxyurea as an Inhibitor of Human Immunodeficiency Virus-Type 1 Replication
Franco Lori, Andrei Malykh, Andrea Cara et al. · Science · 1994 · 321 citations
Klaus Erixon, Gunnar Ahnström · Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis · 1979 · 205 citations
Skin Changes Secondary to Hydroxyurea Therapy
B. J. Kennedy · Archives of Dermatology · 1975 · 186 citations