Publication | Closed Access
Absorption of Drugs Applied to the Gastric Serosal Surface in Rats
18
Citations
0
References
1999
Year
Model DrugsPharmaceutical ScienceGastrointestinal PharmacologyBromphenol BlueLocal PharmacologyGastroenterologyCylindrical Glass CellDigestive TractExperimental PharmacologyMolecular PharmacologyPharmacological StudyDrug AbsorptionPharmacokinetic ModelingBiochemistryDrugs AppliedPharmacologyPhysiologyGastric Serosal SurfaceDrug Delivery SystemsMedicinePharmacokineticsDrug Analysis
The in-vivo absorption of phenol red, bromphenol blue and bromosulphonphthalein, as model drugs, was investigated after application to the rat gastric serosal surface using a cylindrical glass cell. Absorption ratios of model drugs were estimated to be greater than 37% in 4 h. Absorbed drugs appeared gradually in plasma and bile. Drug concentrations in the application site at 1 h were 16–660 times that in the non-application site in the stomach. Drug application to gastric serosal surface was effective with good absorption and efficient delivery to a local site in the stomach.