Phase II trial of preoperative 3D conformal radiotherapy, protracted venous infusion 5-fluorouracil, and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancer

Improved Survival with Preoperative Radiotherapy in Resectable Rectal Cancer

Swedish Rectal Cancer Trial · New England Journal of Medicine · 1997 · 2.5K citations · Full text

Medicine, Oncology, Surgery +14

Improving Adjuvant Therapy for Rectal Cancer by Combining Protracted-Infusion Fluorouracil with Radiation Therapy after Curative Surgery

Michael J. O’Connell, James A. Martenson, Harry S. Wieand et al. · New England Journal of Medicine · 1994 · 1.1K citations · Full text

Medicine, Oncology, Surgery +17

A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study.

J J Lokich, James D. Ahlgren, John J. Gullo et al. · Journal of Clinical Oncology · 1989 · 772 citations

Medicine, Oncology, Pharmacology +15

Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: the M. D. Anderson Cancer Center experience

Nora A. Janjan, Vincent Khoo, James L. Abbruzzese et al. · International Journal of Radiation Oncology*Biology*Physics · 1999 · 468 citations

Medicine, Oncology, Surgery +17

Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma

P. Seifert, Laurence H. Baker, Melvin L. Reed et al. · Cancer · 1975 · 421 citations · Full text

Medicine, Oncology, Pharmacology +16