Hemodynamic and neurohormonal effects of the angiotensin II antagonist losartan in patients with congestive heart failure.

Abstract

Blockade of the angiotensin II receptor with the antagonist losartan causes vasodilator and neurohormonal effects in patients with congestive heart failure. The lack of additional vasodilator response with doses of more than 25 mg suggests that neurohormonal activation might limit the efficacy of high dose of losartan.