Concepedia

Enhanced Sarcoplasmic Reticulum Ca <sup>2+</sup> Leak and Increased Na <sup>+</sup> -Ca <sup>2+</sup> Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

Niels Voigt, Na Li, Qiongling Wang, Wei Wang, Andrew W. Trafford, Issam Abu-Taha, Qiang Sun, Thomas Wieland, Ursula Ravens, Stanley Nattel,

Circulation · 2012 · 603 citations · 47 references

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Abstract

Enhanced SR Ca(2+) leak through CaMKII-hyperphosphorylated RyR2, in combination with larger I(NCX) for a given SR Ca(2+) release and increased diastolic [Ca(2+)](i)-voltage coupling gain, causes AF-promoting atrial delayed afterdepolarizations/triggered activity in cAF patients.

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