Catalytic Enantioselective Hydrophosphonylation of Aldehydes Using the Iron Complex of a Camphor‐Based Tridentate Schiff Base [FeCl(SBAIB‐d)]₂

Abstract

Abstract An iron(III)‐Schiff base‐catalyzed, highly enantioselective hydrophosphonylation of various aldehydes is described. Under the optimized reaction conditions, 5 mol% of the iron/camphor‐based tridentate Schiff base complex [FeCl(SBAIB‐d)] 2 produces high yields (up to 99%) of α ‐hydroxy phosphonates in excellent enantioselectivities (up to 99%). The merits of this catalytic system are an easily synthesizable catalyst, inexpensive starting materials, practically simple aerobic reaction conditions, and low catalyst loading (5 mol%). magnified image