Influence of Order and Type of Drug (Bisoprolol vs. Enalapril) on Outcome and Adverse Events in Patients with Chronic Heart Failure: A <i>post hoc</i> Analysis of the CIBIS-III Trial

Abstract

The order of drug administration plays an important role in whether CHF patients reach target doses of bisoprolol and enalapril. For both study drugs, the dose level reached was associated with baseline characteristics and adverse events. In CHF patients not treated with an ACE-I or a beta-blocker, the duration of monotherapy with either type of drug should be shorter than 6 months.