Synthesis of Pyrazolone Derivatives. XXXII. Studies on (5S,8R)-8,9,9-Trimethyl-5,6,7,8-tetrahydro-5,8-methano-1,2,3-banzotriazine

Abstract

Oxidation of 2-amino-4,7-methanoindazole (5) resulted in ring expansion to afford 5,8-methano-1,2,3-benzotri- azine (2) which showed prominent central stimulation in mice.Irradiation of 3 provided 3-ethynylcyclopentane-"1 carbonitrile ( t ) .We have recently synthesized a series of (4S,7R)-1-or 2-substituted-7,8,8-trimethyl-4,5,6,7-tetrahydro-4,7-methano-l-or 2H-inda-