Concepedia

Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice

Arun Thenappan, Vivek Shukla, Feras J. Abdul Khalek, Ying Li, Kirti Shetty, Pu Liu, Li Lu, Randy L. Johnson, Lynt B. Johnson, Lopa Mishra

Hepatology · 2010 · 40 citations · 27 references

DOIFull text

Open access

Abstract

β2SP deficiency results in dysfunctional hepatocyte cell cycle progression and delayed liver regeneration at 48 hours after PHx, which is p53-independent. β2SP loss may increase susceptibility to DNA damage, impair cell cycle progression, and ultimately lead to hepatocellular cancer.

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27

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