Annals of General Psychiatry · 2008 · 35 citations · 1 references
MedicineNeurologyNeuroscienceClinical NeuroscienceDementiaNeuropsychiatryAlzheimer DiseaseBrain ImagingCognitive ImpairmentDementia TreatmentNeurodegenerative DiseasesNeurodegenerative DisordersAlzheimer's Disease DiagnosisCholinergic Dysfunction In NeurodegenerationDementia ScreeningDementia StagingPharmacological Treatment Of Dementia
Materials and methods Resting EEG was recorded in 20 mild to moderate AD patients (mean age= 75.04 years; 13 women and 7 men; MMSE 15-24) before and after 6 months and 2 years on ChEI (donepezil, rivastigmine, galantamine) treatment. Based on changes of MMSE scores after 2 years follow-up, 11 patients were classified as Non-responders (decrease of MMSE > 2) and 9 patients as Responders (decrease of MMSE < 2). The localization of the differences in activity between two groups (at baseline) and within groups (baseline vs. 6 months) was assessed by voxel-by-voxel ttests of the sLORETA images of the log-transformed computed current density power in seven frequency bands.
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