European Journal of Organic Chemistry · 2010 · 50 citations · 50 references
Natural SciencesChemical EngineeringChemistryCatalysisGreen ChemistryOrganic ChemistryCatalytic MaterialsIndustrial CatalysisAldol ReactionAsymmetric CatalysisAsymmetric SynthesisEnantioselective SynthesisIonic Liquid CatalysisStereoselective Aldol Reactions
Abstract A chiral anion modified ionic liquid derived from L ‐proline proves as a green and efficient asymmetric organocatalyst for direct asymmetric aldol reactions in [BMIm]BF 4 at room temperature. The corresponding aldol products with moderate to good isolated yields (up to 99 %), anti ‐diastereoselectivities (up to 97:3), and excellent enantioselectivities (up to 99 % ee ) were afforded. Recycling of the catalyst and solvent ([BMIm]BF 4 ) was possible up to four runs with a slight reduction in activity.
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