British Journal of Pharmacology and Chemotherapy · 1958 · 11 citations · 3 references
MedicineGynecologyObstetricsPharmacodynamicsReproductive MedicineWomen's Health PharmacotherapyOxytocin PhysiologyPregnancy PharmacologyReproductive PharmacologyUterotonic TherapyAssayComparative Assay EvaluationDose-response Curve AnalysisDose-response Curve FittingDose-response Curve ModelingErgometrine TherapySlope Of Dose-response CurveUterotonic Drug Use
Quantitative assays of oxytocic drugs were performed on the postpartum human uterus by means of external tocography. Since, owing to the rapid involution of the uterus, only two doses could be given to each patient, the assays were designed as incomplete randomized blocks of 2. A dose/response curve for ergometrine was established, and a comparative assay of ergometrine and methly ergometrine carried out, the design and analysis of which is described in detail.
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Statistical Method in Biological Assay
AIBS Bulletin · 1953 · 252 citations
Matthew N. Bainbridge, W. C. W. Nixon, H. O. Schild et al. · BMJ · 1956 · 20 citations · Full text