Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering

SOX9 Is a Potent Activator of the Chondrocyte-Specific Enhancer of the Proα1(II) Collagen Gene

Véronique Lefebvre, Wendong Huang, Vincent R. Harley et al. · Molecular and Cellular Biology · 1997 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

A new long form of Sox5 (L‐Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

Véronique Lefèbvre · The EMBO Journal · 1998 · 802 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival

Ernestina Schipani, Heather E. Ryan, Susanna Didrickson et al. · Genes & Development · 2001 · 792 citations · Full text

Medicine, Cell Biology, Apoptosis +15

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

Darren E. Richard, Edurne Berra, Emmanuel Gothié et al. · Journal of Biological Chemistry · 1999 · 784 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells

Darren E. Richard · Journal of Biological Chemistry · 2000 · 586 citations

Life Sciences, Cell Biology, Physiology +15