Metal-Free Oxidative C(sp³)–H Bond Functionalization of Alkanes and Conjugate Addition to Chromones

Abstract

A metal-free oxidative C(sp(3))-H bond functionalization and subsequent conjugate addition reaction using di-tert-butyl peroxide (DTBP) as the oxidant was established, which tolerates a wide range of simple alkane substrates to react with different substituted chromones for direct preparation of 2-alkylchromanones.